Britain’s Jay Clarke and Cameron Norrie were knocked out of the men’s doubles first round at Wimbledon after a five-set thriller against Marcelo Arevalo and Hans Podlipnik-Castillo.

The pair were leading two sets to one before losing the dramatic fifth set which finished 22-20 on Court 14.

The British duo were handed a wildcard to compete in their first Grand Slam.

But fifth seed Jamie Murray and Bruno Soares beat Paolo Lorenzi and Albert Ramos-Vinolas in three sets.

• Live scores, schedules and results
• Why are so many seeds out already?

It was a comfortable victory for Britain’s Murray and his Brazilian partner – winning their match 7-5 6-2 6-1 in an hour and a half.

Murray is partnering Victoria Azarenka in the mixed doubles and their first-round match against Czechs Lucie Hradecka and Roman Jebavy was suspended a one set all because of bad light.

Teenager Clarke recovered from his earlier five-set loss to join Harriet Dart in a 4-6 6-1 6-4 mixed doubles victory over the Chinese-Swedish pair of Yang Zhaoxuan and Robert Lindstedt.

In the men’s doubles, Liverpudlian brothers Ken Skupski and Neal Skupski beat Nabeel Qureshi and Jean-Julien Rojer 6-4 6-4 7-6 (7-2) to reach the third round..

Compatriot Joe Salisbury is also through to round three with his Danish partner Frederik Nielsen after their opponents Rohan Bopanna and Edouard Roger-Vasselin retired two sets and 3-2 down in the third.

Dominic Inglot and Franko Skugor came through to win 6-3 4-6 7-6 (7-5) 2-6 6-2 in five sets against Santiago Gonzalez and Marcelo Demoliner.

Ken Skupski was back in action later in the day, alongside fellow Briton Anna Smith, to make it through to the mixed doubles second round with a 6-1 6-7 (3-7) 7-5 victory over Nicholas Monroe and Oksana Kalashnikova.

Heather Watson and her partner Tatjana Maria also ensured they had a place in the third round of the women’s doubles with a routine 6-3 6-1 win over Raquel Atawo and Anna-Lena Gronefeld.

But Luke Bambridge and Katie Boulter were knocked out of the mixed doubles event at the first stage, losing two tie-breaks against Andrei Vasilevski and Arina Rodionova.

And in an all-British affair, it was Neal Skupki and Naomi Broady who came through as winners in the mixed doubles first round with a two-set victory over Salisbury and Katy Dunne.

There were more shock exits in the women’s singles draw on day five at Wimbledon.

But elsewhere Nick Kyrgios still grabbed the headlines, Roger Federer and Serena Williams continued to dominate on Centre Court and there was a three-day, five-hour, five-set thriller involving two Britons in the men’s doubles.

Here are five things from Wimbledon day five.

Federer sweeps aside Struff

Top seed Federer was flawless yet again.

Whatever Germany’s Jan-Lennard Struff threw at him, he had an answer and it was in typically emphatic fashion that he made it through to round four with a 6-3 7-5 6-2 win on Centre Court.

The defending champion needed just one hour and 34 minutes to win – a much easier ride than his next opponent Adrian Mannarino, who had to come from behind in the fifth set to make it through to the last 16.

The Swiss has still not even dropped a set at Wimbledon this year – extending his winning streak to 29 in a row – and he looks full of energy.

• Federer continues flawless tournament
• How can Kyle Edmund beat Novak Djokovic?
• Monfils beats Querrey – men’s round-up

Venus the latest star to fall

Five-time Wimbledon champion Venus Williams was the biggest casualty on another tough day for the seeded players.

Eight of the top 10 seeds in the women’s singles have now failed to make it through to the last 16.

“Some of it is players not having a plan B, or plan C,” former Australian Open semi-finalist Chanda Rubin told BBC Sport.

“You have to somehow find a way to win on those days when you are not at your best and some of the top players just haven’t been able to do that.”

• Why are so many seeds out of Wimbledon?

Ninth seed Williams, 38, was beaten 6-2 6-7 (5-7) 8-6 by 26-year-old Dutchwoman Kiki Bertens.

Williams’ fellow American Madison Keys, 23, also exited after an erratic 7-5 5-7 6-4 loss to Russian qualifier Evgeniya Rodina who is ranked 120th in the world.

Romanian Mihaela Buzarnescu fought back the tears as she lost 3-6 7-6 (7-3) 6-1 to Czech seventh seed Karolina Pliskova.

Russian Ekaterina Makarova, Germany’s Julia Goerges and Donna Vekic of Croatia all progressed.

Serena improves again in third showing

While many around her are falling, Serena Williams is only growing in stature.

She came through her first proper test against France’s Kristina Mladenovic 7-5 7-6 (7-2) despite going a break down in the first set.

The 23-time Grand Slam champions still hasn’t dropped a set and with eight of the top 10 women’s seeds now out, the road is clearing rapidly towards an eighth Wimbledon title.

“Just getting to the round of 16 twice is not bad. Hopefully I can do a little bit better,” she said. “I don’t have anything to lose. I have absolutely nothing to prove.”

• Serena Williams powers into round four

Britons come out on wrong side of 42-game final set

With only one home player left in action in the singles draws, attentions turned to the doubles, where eight Britons made it through.

Jay Clarke and Cameron Norrie did not but they were involved in an epic five-hour battle on court 14 against first-round opponents Marcelo Arevalo and Hans Podlipnik-Castillo.

The match began on Wednesday and was suspended with the Britons 3-2 up in the first set because of rain. It resumed on Thursday but bad light forced another stoppage with Clarke and Norrie two sets to one up and leading 4-6 7-6 (7-5) 7-5 4-3.

Arevalo and Podlipnik-Castillo bounced back to take the fourth set 6-4 on Friday. The players tussled back and forth in the fifth and final set, before Clarke and Norrie lost it 22-20 in front of a highly entertained crowd.

It was the first time the two Britons were playing together at a Grand Slam after they were handed a wildcard to compete in the men’s doubles – and it was certainly a match to remember.

• Round-up of all the doubles action

Kyrgios at the centre of it all again

Kyrgios has already caused controversy at this year’s Wimbledon championships and he did so again on Friday without even lifting a racquet.

After getting caught up in two exchanges with umpire James Keothavong on Thursday, receiving a code violation for inappropriate language, the Australian 15th seed has now caused further sparks with his social media use.

He went on Instagram to respond to criticism from 2013 champion Marion Bartoli after she said he was “childish” and lacks “work ethic” on Radio 5 live on Thursday.

Kyrgios asked Bartoli to “stop assuming you know what’s best for others” in a lengthy post which he signed off with the words: “we don’t care what you have to say”.

He faces Japan’s Kei Nishikori in the third match on Court One on Saturday.

Fourth seed Alexander Zverev beat Taylor Fritz 6-4 5-7 6-7 6-1 6-2 in the second round of Wimbledon after a suspension in play overnight.

Play was halted because of bad light on Thursday with world number three Zverev two sets to one behind on Court One.

But the German bounced back in emphatic style to win the following two sets as Fritz struggled to regain his form.

The American, ranked 68th, held on early in the fifth but Zverev then broke away to reach round three.

The 21-year-old is yet to win a Grand Slam but picked up his fourth ATP title in New York in February.

“Unfortunately we are out in the football,” he told BBC Sport, referring to Germany being eliminated form the World Cup in Russia at the group stage.

“But hopefully I can win a few more matches here and the crowd can have something to cheer about.”

In the third round, South African eighth seed Kevin Anderson, who reached the 2017 US Open final, beat German fifth seed Philipp Kohlschreiber 6-3 7-5 7-5.