MELBOURNE, Australia – Simona Halep and Garbiñe Muguruza will open their 2016 Australian Open accounts on Tuesday in Melbourne, as will Venus Williams and a host of other top players. Here’s a rundown of what’s to come.

Tuesday, Day 2
First Round

[3] Garbiñe Muguruza (ESP #3) vs. Anett Kontaveit (EST # 85)
Head-to-head: First meeting
Key Stat: Muguruza owns a 7-3 record at the Aussie Open in three appearances.

What can one of the WTA’s biggest breakout stars of 2015 possibly do for an encore in 2016? We’ll soon find out as the explosive Garbiñe Muguruza readies herself for a first-round encounter with Estonia’s Anett Kontaveit. “For sure I want to do better,” Muguruza told reporters when asked about how she’d like to perform in 2016. “I know this is a very important tournament for us, so it’s where you want to do well.” Though inexperienced, the Spaniard’s first-round opponent has proven to be a tough out at majors already in her young career. Kontaveit won her first career Grand Slam match then rolled all the way to the second week of last year’s U.S. Open, before finally falling to Venus Williams in the round of 16.

Pick: Muguruza in three

[8] Venus Williams (USA # 10) vs. Johanna Konta (GBR # 47)
Head-to-head: Williams Leads 1-0
Key Stat: Konta served for the match against Williams at Wuhan last year, but ended up losing 7-5 in the third.

Venus Williams reached the quarterfinals of both hard court majors in 2015—a feat that she hadn’t accomplished since 2010—and the 35-year-old has experienced a run of form that has landed her the No. 8 seed in Melbourne. So is it high time for the seven-time major champion to defy our expectations once again and wreak some havoc down under? To do that Williams will have to get past rising Brit Johanna Konta. Ranked 98 spots higher in the rankings than she was at this time last year, Konta has grown by leaps and bounds. She upset Garbiñe Muguruza at the U.S. Open last year en route to her first round of 16 at a major, and despite the fact that she’s gone 0-2 thus far in 2016, she comes in with newfound confidence in her game on the big stage.

Pick: Williams in three

[14] Victoria Azarenka (BLR #16) vs. Alison Van Uytvanck (GER# 43)
Head-to-head: First meeting
Key Stat: Van Uytvanck has jumped 66 rankings spots in the last year, rising from 106 to her current perch at 44.

With all the injuries ailing the top five players heading into Melbourne, many have tabbed two-time Australian Open champion Azarenka as a favorite to take the title down under. And why shouldn’t they? For the first time in what feels like eons, Azarenka is in perfect health. And she started the season by ripping through the Brisbane draw, tying the record for fewest games dropped during a title run. Though she’ll face a stern test in rising star Alison Van Uytvanck in the first round, Azarenka isn’t about to let the pressure get to her. “I just feel excited,” Azarenka said. “Not thinking about the chances. As I said, I try to live in the moment. Carpe diem.”

Pick: Azarenka in two

[2] Simona Halep (ROU #2) vs. [Q] Shuai Zhang (CHN # 132)
Head-to-head: Halep leads, 1-0
Key Stat: Halep entered 2014 with a 10-14 record at the majors. She’s gone 27-8 at Grand Slams in the last two seasons.

Despite being troubled by left Achilles soreness off and on for the last two weeks, No. 2 seed Halep told reporters over the weekend that she’s in good stead. “I feel good now,” she asserted. “I played many days without pain. So I feel ready to start and hopefully to be healthy till the end.” If that’s the case then Halep could very well make a deep run in Melbourne. The 24-year-old freely admits it is on her to-do list. “I think to win a Grand Slam, I don’t know if it’s going to happen this year, but this is my biggest goal,” she told reporters on Sunday. Halep’s opponent, Shuai Zhang, will certainly have her hands full with the world No. 2. She enters Melbourne with a 0-14 record in Grand Slam main draw matches, having won just two sets.

Pick: Halep in two

Around the Grounds: Still seeking a major breakthrough, 9th-seeded Karolina Pliskova will face the youngest woman in the draw, 17-year-old wild card Kimberly Birrell of Australia… A semifinalist last year in Melbourne, American Madison Keys gets things underway with a battle against Zarina Diyas of Kazakhstan… American Victoria Duval will play her first Grand Slam match since being declared cancer-free last year. She enters on a protected ranking, and will play her first tour-level match since Wimbledon 2014. Her opponent will be 18th-seeded Elina Svitolina.