World number one Naomi Osaka’s defence of her Indian Wells title was ended in round four by Belinda Bencic.

Japan’s Osaka, who holds the US Open and Australian Open titles, was beaten 6-3 6-1 by the Swiss world number 23 in just over an hour.

World number two Simona Halep or Romania is also out, beaten 6-2 3-6 6-2 by Czech teenager Marketa Vondrousova.

It was a first win over a top-five player for the 19 year old, who is ranked 61st in the world.

• Djokovic out in Indian Wells third round
• Live scores, schedule and results

Halep’s defeat in California means 21-year-old Osaka, who claimed her first WTA title with victory at Indian Wells last year, will keep her number one ranking, despite losing to 22-year-old Bencic.

“I didn’t play that well,” Osaka said. “Honestly, at a time like this with that scoreline, I would usually feel very depressed and sad.

“But I feel pretty good right now because I tried my best and I don’t really have any regrets.

“She was just playing so well. There wasn’t anything that I could do in that situation.”

Bencic, who beat four top-10 players on the way winning a title in Dubai last month, faces world number five Karolina Pliskova, who beat Anett Kontaveit 7-6 (7-0) 4-6 6-2, in the quarter-finals.

“I’m very confident with my game right now. I’m hitting the ball well. So just things worked out for me,” said Bencic.

Vondrousova had defeated 2017 French Open champion Jelena Ostapenko and last year’s Indian Wells finalist Daria Kasatkina prior to beating Halep.

“I was running a lot – I felt like I was dying for a moment,” Vondrousova joked in an on-court interview.

“I’m so happy to be through and so happy with my play.”

She will play Ukraine’s Elina Svitolina, who beat Australian Ashleigh Barty 7-6 (10-8) 5-7 6-4, in the next round.

Vondrousova served for the match at 5-1 in the third set but was broken to 15, before breaking back in a scrappy game from Halep to seal the win.

French Open champion Halep, who is still without a permanent coach, has not won a WTA title since the Canadian Open in August.

Canada’s Bianca Andreescu, 18, continued her remarkable season with a 7-5 6-2 win over China’s Wang Qiang.

Andreescu, who beat Caroline Wozniacki and Venus Williams on her way to the Auckland Open final in January, has won 23 and lost just three matches this year.

She will play Spain’s Garbine Muguruza next, after the former world number one beat Kiki Bertens 5-7 6-1 6-4.

World number one Novak Djokovic was knocked out of the BNP Paribas Open in the third round by Philipp Kohlschreiber at Indian Wells.

The Serb, who currently holds three of the four Grand Slam titles, was beaten 6-4 6-4 by the German world number 39.

Djokovic broke his racquet in anger after Kohlschreiber – who had lost his past seven matches against the 31-year-old – took the first set.

Britain’s Kyle Edmund beat Radu Albot 6-3 6-3 to reach the last 16.

He will face either Roger Federer or Stan Wawrinka next with the Swiss pair meeting in Tuesday’s night session in California.

The match between Djokovic and Kohlschreiber began on Monday but was delayed until Tuesday because of heavy rain.

Kohlschreiber won 72% of first-serve points and saved four of five break points as he closed out victory.

He will play French 18th seed Gael Monfils in the fourth round.

• Halep beaten by teenager Vondrousova in Indian Wells
• Live scores, schedule and results

Second seed Rafael Nadal reached the fourth round with a 6-1 6-4 win over Diego Schwartzman.

Nadal, a three-time champion at Indian Wells, did not face a break point in the match.

He will play Serbia’s Filip Krajinovic next after Krajinovic, ranked 113, beat 15th seed Daniil Medvedev 6-3 6-2.

Elsewhere, Canadian 19-year-old Denis Shapovalov rapped on court in his post-match interview after beating Croatian 10th seed seed Marin Cilic.

Shapovalov, seeded 24th at Indian Wells, beat the 2014 US Open champion 6-4 6-2 and will play Poland’s Hubert Hurkacz next.

Hurzack, ranked 67 in the world, fought back to beat Japanese sixth seed Kei Nishikori 4-6 6-4 6-3.