Ten years ago, Roger Federer and Rafael Nadal contested a Wimbledon final which many believe is the greatest tennis match ever played.

Now aged 36 and 32 respectively, the top-seeded pair are each two wins away from a romantic rematch.

But first they have to negotiate their quarter-final matches on Wednesday.

While Federer, Nadal and fellow all-time great Novak Djokovic are old hands at reaching this stage, there are three debutants in the SW19 quarter-finals in Kevin Anderson, Kei Nishikori and John Isner.

Meanwhile, 2016 runner-up Milos Raonic and 2009 US Open champion Juan Martin del Potro are in familiar territory.

Here, with the help of two-time Wimbledon champion Andy Murray, BBC Sport looks at how the last eight men standing match up…

• Has Djokovic rediscovered his mojo?
• Live scores, schedule and results

Roger Federer (Swi) [1] v Kevin Anderson (SA) [8]

Federer’s progress through the draw has been smooth and serene, not dropping a set nor losing a service game on his way to an Open era record 53rd Grand Slam quarter-final.

Another straight-set win over Anderson will see the Swiss great better his record run of 34 consecutive sets at SW19, which he enjoyed between the third round in 2005 and the final in 2006.

“I don’t think it’s something anybody aims for, to win every match in straight sets,” Federer said.

“I hope I get off to a good start, go from there. If it happens, it happens.”

Anderson, 32, is one of the biggest servers on tour and the hot conditions are helping his game. However, the 2017 US Open finalist has never taken a set off Federer in four previous meetings.

Andy Murray’s verdict: “Roger is playing well and moving well, and against Anderson he leads 4-0 in their head-to-head. So I feel comfortable he would get through.

“It would take an unbelievable serving performance from Anderson. If he serves 80% first serves and Roger has a really bad serving day, then he might have a chance.”

Milos Raonic (Can) [13] v John Isner (US) [9]

A battle of the big servers is likely to see plenty of baseline rallies and not much court-craft.

Between them, Raonic and Isner occupy the top two places in the ace count and fastest serves standings.

Isner has a higher percentage of landed first serves than anyone else, while only Federer has won more points on his first serve than Raonic.

“There’s a good chance it’s going to come down to a few points here and there,” said Isner. “It’s strength on strength, for sure.”

Raonic has the greater experience at Wimbledon, however, reaching at least the last eight in four of his past five appearances here – including a run to the 2016 final where he was beaten by home favourite Andy Murray.

“It’s a surface that’s going to allow me to come forward more,” he said. “It’s going to help my volleys when I’m at the net stay a little bit lower, these kind of things.

“It’s harder for other guys to move. If they’re not moving as well, it’s hard for them to be in balance for passing shots.”

Andy Murray’s verdict: “This is tie-breaks. Isner is 3-1 up head to head and that’s a bit surprising for me. Raonic is maybe a little bit more comfortable on the grass than John but that is an impossible match to pick. I wouldn’t want to bet on that one.”

Novak Djokovic (Ser) [12] v Kei Nishikori (Jpn) [24]

To claim Djokovic is back to his 12-time Grand Slam winning best would be a tad premature, but the 31-year-old Serb is getting closer to it.

The three-time champion, who has not reached a Slam semi-final since the 2016 US Open, clinically despatched Karen Khachanov in the last 16 and will be considered favourite to beat Nishikori.

Djokovic has beaten the Japanese 24th seed in 13 of their 15 meetings.

“So far four matches have been really, really good for me,” said Djokovic, who eliminated British number one Kyle Edmund in the third round.

“I haven’t spent too much time on the court. I feel physically, mentally ready, fit, positive.”

Former world number four Nishikori, who has never faced Djokovic on grass, has lost twice to him this year on clay.

“It’s always like a big war for me,” said Nishikori on facing Djokovic. “It’s always a big challenge.”

Andy Murray’s verdict: “In terms of his level and the way he’s playing, I think Novak is back to where he wants to be. Mentally he looks where he needs to be – looks fired up and motivated. He’s got a great shot.”

Juan Martin del Potro (Arg) [5] v Rafael Nadal (Spa) [2]

Like his great rival Federer, Nadal has reached the last eight without dropping a set.

The 32-year-old looks refreshed following his decision to pull out of Queen’s and now, unlike Del Potro, has had the benefit of a day off.

Del Potro was forced to finish his last-16 match against Gilles Simon on Tuesday because of fading light on Monday, but said afterwards he felt he would be in a “good condition”.

The Argentine is one of the most popular players among tennis fans, not least because he has had to overcome serious wrist injuries which left him contemplating retirement.

But he persevered through dark times and is rewarded with his second successive Slam quarter-final – the first time he has done that since reaching the last eight at both the Australian Open and Roland Garros in 2012.

The fifth seed lost to Nadal in the Paris semi-finals last month, however.

“It will be a different match that we played in Paris few weeks ago,” he said. “I will try to hold my service games most of the time.

“If I want to beat him, I have to come to the net very often and play hard with my forehands, with my backhands, and try to take all the chances.”

Murray’s verdict: “Nadal faces a tough match against Del Potro. If Del Potro is physically there – I saw some of his match against Gilles Simon on Monday and he seemed to have some issues – that’s not an easy match.”

Federer makes rare appearance on Court One

Eight-time champion Federer will play on Court One for the first time since the 2015 quarter-finals, with former world number one Djokovic’s match against Nishikori put on Centre.

The Serb has only played once on Centre this year – his third-round win over Edmund.

He has played twice on the 11,000-capacity Court One this year, and once on the 4,000-seater court two for his second-round clash against Horacio Zeballos.

Murray’s verdict: “Rafa and Del Potro has to be on Centre – that is the best match of the quarters.

“The fans on Court One will love seeing Roger and while some ticket holders on Centre might be upset, they have two brilliant matches to look forward to.”

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Britain’s Jamie Murray and Brazilian Bruno Soares are through to the quarter-finals of the men’s doubles at Wimbledon.

They comfortably beat British brothers Ken and Neal Skupski 6-3 6-4 6-4.

Murray and Belarusian partner Victoria Azarenka later reached the mixed doubles third round with a thrilling late-night 7-6 (8-6) 6-7 (6-8) 7-5 win over Anna-Lena Gronefeld and Robert Farah under the roof on Centre Court.

They had trailed 5-1 in the final set.

Murray and Soares, the 2016 Australian Open and US Open champions, are yet to win a Wimbledon men’s doubles title but reached the final in 2015.

They will face 13th seeds Raven Klaasen and Michael Venus next.

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Britain’s Joe Salisbury and partner Frederik Nielsen of Denmark booked their place in the last eight with victory over Farah and his fellow Colombian Juan Sebastian Cabal.

Salisbury and Nielsen lost the first set but fought back to beat the sixth seeds 5-7 7-6 (7-3) 6-3 7-6 (7-1).

In the women’s doubles, Britain’s Heather Watson and German Tatjana Maria are through to the last eight after a walkover against Jelena Ostapenko and Christina McHale.

Ostapenko withdrew to concentrate on her quarter-final in the singles.

Top seeds Timea Babos and Kristina Mladenovic clinched a 6-3 6-4 win over Kirsten Flipkens and Monica Niculescu.

Second seeds Andrea Hlavackova and Barbora Strycova were knocked out 2-6 7-6 (9-7) 6-4 by Bethanie Mattek-Sands and Lucie Safarova, who have won five Grand Slam titles together but are yet to triumph at Wimbledon.

Watson and Finland’s Henri Kontinen – who are seeded 16th – triumphed 6-2 5-7 7-5 in their mixed doubles second-round match against Marcin Matkowski and Mihaela Buzarnescu.

The top 10 seeds are all out and Serena Williams has been grabbing all the headlines, but who stands between her and an eighth Wimbledon singles title?

The highest-ranked player to reach Tuesday’s quarter-finals is 11th seed Angelique Kerber – who Williams was quick to point out is actually the world number 10. Kerber, Williams and Jelena Ostapenko are the only Grand Slam champions left.

This is the first time since seedings were introduced in 1927 that none of the top eight women has made it through to the quarter-finals here.

Here we look at who’s who in the last eight.

Angelique Kerber v Daria Kasatkina

Kerber, the 2016 Australian Open and US Open champion, says she is “not feeling the pressure” of being the top seed left.

The German former world number one has played Kasatkina six times, winning half of them, but has lost twice to the Russian this year – including in last month’s Eastbourne quarter-finals.

A left-hander, the 30-year-old – who reached the Wimbledon final in 2016 – is appearing in the last eight at the All England Club for a fourth time.

Kasatkina, 21, is into her first Wimbledon quarter-final but is much more relaxed than when she reached the same stage at Roland Garros this year.

“This is what I call experience,” she said. “You’re getting used to these things. It’s really good because I will go on the court with the feeling that it’s just the next match, it’s not like something huge. I will be not that stressed, for sure.”

Asked how she would describe herself to people who did not know much about her, Kasatkina replied: “I’m just like an artist and I’m playing with the heart.”

Jelena Ostapenko v Dominika Cibulkova

Cibulkova would have been seeded, had it not been for the decision by the All England Club to give a seeding to Williams despite her world ranking of 181.

The Slovak, 29, was vocal about how it was “not fair” and has been playing at this tournament as if fired up by a sense of injustice.

The 2014 Australian Open runner-up is in the opposite side of the draw to Williams, so could still get a chance to make her point across the net in the final.

Cibulkova, who knocked out Britain’s Johanna Konta in the second round, has yet to drop a set here.

She faces Ostapenko, who became Latvia’s first Grand Slam champion when she won the French Open in 2017 as an unseeded 20-year-old.

Her title defence ended in the first round this year but she says she is playing more freely because the pressure of defending a title has gone.

“I’m just not afraid to miss,” she said. “I think I’m serving very well this tournament. In general, I think my level is much better than in the last Grand Slam.”

Kiki Bertens v Julia Gorges

Twentieth seed Bertens and 13th seed Gorges will be appearing in their first Wimbledon quarter-final.

The pair are friends, and have played doubles together.

A French Open semi-finalist in 2016, Dutchwoman Bertens’ five WTA titles have come on clay and she says she is “surprised” to have made it this far at the grass-court Grand Slam.

On her way to the last eight she beat five-time champion Venus Williams and seventh seed Karolina Pliskova, the latter of whom was the only top-10 seed to reach the fourth round.

“It’s going to be tough. We know each other so well,” Bertens, 26, said. “It’s going to be really exciting.

German 29-year-old Gorges lost the Charleston final to Bertens 6-2 6-1 earlier this year.

Serena Williams v Camila Giorgi

Asked what she most liked about what she had seen of Williams over the years, world number 52 Camila Giorgi replied: “I don’t follow tennis.”

But even if you do not follow the sport, you probably know all about the 23-time Grand Slam champion, who is on a comeback from having a baby last September.

With the seeds tumbling at a rapid rate, Williams is many peoples’ favourite for the title and is yet to drop a set, though she is also yet to face a top-50 player.

Giorgi, who has one WTA title to her name, is appearing in her first Grand Slam quarter-final and is the first Italian to reach the last eight at Wimbledon since Francesca Schiavone in 2009.

She describes herself as an “aggressive” player, and is likely to need to be just that on Centre Court on Tuesday.