Roger Federer and Andy Murray, who have combined to win nine of the past 13 Western & Southern Opens, could meet in a blockbuster third-round clash in Cincinnati. And while fans will salivate over that possible meeting between two former World No. 1s, there is plenty to watch out for with top seed Rafael Nadal, defending champion Grigor Dimitrov and 69-time tour-level titlist Novak Djokovic all getting placed in a stacked top quarter.

If Federer moves past Peter Gojowczyk or Joao Sousa and Murray defeats 16th seed Lucas Pouille and then Leonardo Mayer or a qualifier, the superstars will face one another for the 26th time in their FedEx ATP Head2Head series. It would be their first meeting since the same tournament three years ago.

Murray is competing in just his fourth tournament in nearly 14 months, continuing his comeback from hip surgery in January. And if he plays Federer, he will try to overcome a five-match losing streak against the Swiss. Federer, who leads their rivalry 14-11, has triumphed in three of their four battles in Cincinnati, with their past three meetings at the event (2009, 2014, 2015) coming in the quarter-finals or later.

The rest of their quarter is full of standouts as well, as whoever emerges from their section will likely face eighth seed Dominic Thiem, 12th seed Diego Schwartzman, former World No. 3 Stan Wawrinka or Japanese star Kei Nishikori in the quarter-finals.

All eyes will be on the top quarter, though, with four current or former Top 3 players in the ATP Rankings looking to make their mark at the ATP World Tour Masters 1000 event. Nadal could possibly meet Canadian Milos Raonic in his opener, so long as the eight-time titlist advances past a qualifier.

The Spaniard, who triumphed in Cincinnati five years ago, could eventually face Dimitrov or Djokovic in the quarter-finals. Dimitrov lifted his first Masters 1000 title in Ohio one year ago, while Djokovic is trying to complete the career ‘Golden Masters’, as Cincinnati is the only tournament at the elite level he has not yet won. The duo could meet in the third round, with a second-round clash against Marco Cecchinato, who beat Djokovic in the Roland Garros quarter-finals, looming for the Serbian.

Third seed Alexander Zverev, a three-time Masters 1000 winner, is projected to meet 2016 champion Marin Cilic in the quarter-finals. Fourth seed Juan Martin del Potro, who is pursuing his second title at this level, will potentially meet sixth seed Kevin Anderson in the last eight.

But don’t wait for all of those possible matches to come to fruition, as you can grab popcorn for plenty of meetings in the first round.

#NextGenATP Greek Stefanos Tsitsipas, who on Friday at the Rogers Cup became the youngest player to beat three Top 10 players at a single tournament since Rafael Nadal at the 2006 Monte-Carlo Masters, will face 2017 Nitto ATP Finals runner-up David Goffin in his opener. The 19-year-old has won two of three FedEx ATP Head2Head meetings against the Belgian, including a victory last October in Antwerp to reach his maiden ATP World Tour semi-final.

An all-#NextGenATP opener also promises to be a thriller, with Canadian Denis Shapovalov and American Frances Tiafoe clashing for the second time. Tiafoe beat the left-hander in the Delray Beach Open semi-finals earlier this season en route to his maiden tour-level title.

Other First-Round Matches To Watch:
– No. 9 John Isner vs. Sam Querrey

– Jack Sock vs. Hyeon Chung

– Kei Nishikori vs. Andrey Rublev

– No. 12 Diego Schwartzman vs. Stan Wawrinka

#NextGenATP Greek Stefanos Tsitsipas produced a stunning comeback on Friday, saving two match points to upset defending champion Alexander Zverev 3-6, 7-6(11), 6-4 at the Rogers Cup.

The 19-year-old hit 28 winners, including 18 on his forehand side, to stun the second seed after two hours and 27 minutes. Tsitsipas becomes the youngest player since Rafael Nadal in 2006 (Monte-Carlo) to conquer three Top 10 opponents in a single tournament.

Tsitsipas will face Kevin Anderson for a place in Sunday’s final. Anderson defeated reigning Nitto ATP Finals champion Grigor Dimitrov 6-2, 6-2 to reach his maiden semi-final at the event.

World No. 1 Rafael Nadal continues his bid for a fourth Rogers Cup crown on Friday, with Nitto ATP Finals qualification on the line in the Toronto quarter-finals, which features five of the Top 10 in the ATP Rankings. At one end of the spectrum, Spanish superstar Nadal appears in his 86th ATP World Tour Masters 1000 quarter-final (66-19), while Greek Stefanos Tsitsipas and Karen Khachanov of Russia contest their first on the hard courts of Toronto.

View FedEx ATP Head2Head for the Rogers Cup & vote for who you think will win! 
Nadal vs Cilic | Zverev vs Tsitsipas | Anderson vs Dimitrov | Haase vs Khachanov

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Nadal, who beat former World No. 3 Stan Wawrinka on Thursday night, is set for another blockbuster against World No. 7 Marin Cilic during the night session and victory would see him become the first singles player to clinch a spot at the 2018 Nitto ATP Finals, to be held at The O2 in London from 11-18 November. Aiming to capture a record 33rd Masters 1000 crown (and third of 2018), Nadal won the Canadian crown in 2005 (d. Agassi), 2008 (d. Kiefer) and 2013 (d. Raonic).

Cilic, who is through to the Rogers Cup quarter-finals for the first time since 2008, was leading Nadal in their Australian Open quarter-final in January, when his opponent retired due to a right hip injury. The 32-year-old Nadal, who leads Cilic 5-2 in their FedEx ATP Head2Head series (4-2 on hard courts), is seeking his eighth Masters 1000 hard-court title and first since winning the BNP Paribas Open, Montreal and the Western & Southern Open in 2013.

Tsitsipas could become the youngest player to post three Top 10 wins at a single tournament since Nadal, then 19, in April 2006 at the Rolex Monte-Carlo Masters should the 19-year-old #NextGenATP star beat defending champion Alexander Zverev. The Greek has also knocked out Dominic Thiem and Novak Djokovic this week, while Zverev needs to lift his fourth Masters 1000 crown in order to hold off Juan Martin del Potro and remain at No. 3 in the ATP Rankings on 13 August. Six days ago, Zverev beat Tsitsipas 6-2, 6-4 in the Citi Open semi-finals in Washington, D.C.

World No. 5 Grigor Dimitrov, a few days shy of attempting to retain the Cincinnati crown (d. Kyrgios), has won seven of his past nine matches against Top 10 opponents and looks to be returning to top form ahead of his match-up against No. 6-ranked Kevin Anderson, the recent Wimbledon finalist. Anderson is 1-10 in Masters 1000 quarter-finals, having reached the last four at the Mutua Madrid Open in May, but Dimitrov leads their FedEx ATP Head2Head series 6-1 (3-1 on hard courts).

Dutchman Robin Haase, who is playing some of the best tennis of his career at the age of 31, looks to reach the Toronto semi-finals for the second consecutive year (2017, l. to Federer) with victory over Khachanov, who has held serve this week in 31 of his 32 service games, including victories over No. 12 seed Pablo Carreno Busta and eighth seed John Isner. One place in the ATP Rankings separates No. 38-ranked Khachanov from Haase (No. 39) ahead of their first-time meeting.