Andy Murray shook off whatever rust there was from Indian Wells and looked comfortable in a familiar environment on Saturday night at the Miami Open presented by Itau.

Murray, who has a home in Miami, won in straight sets against Denis Istomin of Uzbekistan 6-3, 7-5 in his first match since losing to Argentina’s Federico Delbonis at the BNP Paribas Open last week.

The No. 2 seed broke Istomin four times and performed close to the level Miami fans have come to expect from the Brit. Murray has won the Miami tournament two times (2009, 20013) and finished as a finalist twice as well (2012, 2015).

“I feel comfortable there,” Murray said last week of Miami.

The 28 year mixed spin with power to land 24 winners. He broke Istomin to start the match and never relinquished his serve during the opening set. An Istomin forehand long gave Murray another break and a one-set lead.

In the second set, the two traded holds until Murray netted a forehand to hand Istomin his first break of the match. But down 2-3, Murray played inspired tennis. He broke Istomin at love. Murray then held to go up 4-3 and finished the match by breaking Istomin at 6-5.

It was not Murray’s cleanest match of 2016, though. He landed only 52 per cent of his first serves and committed 24 unforced errors.

Istomin was looking for his second win in the past six months. The World No. 76 upset Croatia’s Borna Coric in Miami for his first win of 2016. With Saturday’s loss, Istomin fell to 1-30 lifetime against Top 10 players.

Murray will face Bulgarian Grigor Dimitrov in the third round. Dimitrov overcame seven double faults to beat Delbonis 7-6(8), 4-6, 6-4. Murray leads their FedEx ATP Head2Head rivalry 6-2. The Brit also has won their last three meetings on hard courts.

No. 9 seed Jo-Wilfried Tsonga also moved into the third round on Saturday evening. The Frenchman used four service breaks to bypass Colombia’s Santiago Giraldo 6-3, 6-1.

Bob Bryan and Mike Bryan’s quest for history remains intact at the Miami Open presented by Itau. The American duo won their first-round match against the Spanish team of Inigo Cervantes and David Ferrer 6-3, 7-5 on Saturday to move into the second round.

The reigning two-time Miami Open champions are looking to become the first doubles team to win three consecutive titles in Miami since Todd Woodbridge and Mark Woodforde from 1995-97.

Bob Bryan and Mike Bryan, who have won four Miami titles, next will play Spaniard Roberto Bautista Agut and Serbian Viktor Troicki. They beat Great Britain’s Dominic Inglot and Sweden’s Robert Lindstedt 6-3, 7-5 on Thursday.

A potential roadblock for the Bryans lost on Saturday. No. 1 seeds Jean-Julien Rojer of the Netherlands and Horia Tecau of Romania fell to Frenchmen Jeremy Chardy and Fabrice Martin 6-7(7), 6-7(4).

The Frenchmen will meet the Spanish team of Feliciano Lopez and Marc Lopez in the second round.

The other seeded doubles team playing on Saturday also was upset. No. 7 seeds Edouard Roger-Vasselin of France and Nenad Zimonjic of Serbia fell to Omar Jasika and John-Patrick Smith, the wild-card team from Australia, 1-6, 7-5, 10-12.

The Aussies advanced to the second round to face Spaniard David Marrero and Frenchman Benoit Paire.

Rafael Nadal was forced to retire against Damir Dzumhur on a hot and muggy Saturday at the Miami Open presented by Itau. Dzumhur, No. 94 in the Emirates ATP Rankings, was up 2-6, 6-4, 3-0 in the second-round match when the Spaniard was unable to continue. Dzumhur had never beaten a Top-10 player in five previous attempts.

“Everything was fine until the end of the first set,” Nadal said. “Then I started to feel dizzy, not very good. It was getting worse and worse. Finally, in the second set, I realised that I could not keep playing.

“I wanted to finish the match, but I seriously could not. It was tough, because I felt I was playing well. I had good practices after a great week in Indian Wells. I stopped because I was concerned for my health, and I could not finish the match the way I was feeling.”

Despite its final outcome, the match did not start auspiciously for Dzumhur. The Bosnian faced 12 break points in losing the one-sided opening set, and was the first to request the trainer. The 23 year old was visibly affected by Miami’s heat and humidity, but soldiered on after receiving assistance during the changeover.

Nadal was unable to capitalise on Dzumhur’s discomfort. After breezing through his service games in the opening set, the left-hander won only 50 per cent of first-serve points the rest of the way (11/22) and was broken four times in as many opportunities in the last two sets. An ailing Nadal called for the trainer twice before retiring after an hour and 50 minutes. The Spaniard, a four-time finalist in Miami, will have to wait another year to capture the elusive title.

“It’s definitely not the way I wanted to finish,” Dzumhur said. “It was really tough to play today. I also felt tired, heavy, and in some moments dizzy on the court. In the first set we played a very long second game. After that game I felt I could not run that well.

“Between the first and second sets, I calle a medical time-out. I was really thinking about retirement, but just said to myself, ‘I’m playing Rafa. I don’t have a chance to play these guys every day. I want to enjoy this moment.’ So I tried to continue.”

In the third round, Dzumhur will face Mikhail Kukushkin, who advanced when Thomaz Bellucci retired at 7-5, 3-6. The Kazakh, No. 90 in the Emirates ATP Rankings, is into the third round in Miami for the first time. His previous third-round appearance in an ATP World Tour Masters 1000 event dates back to Indian Wells 2014 (l. to Lopez).

The best season of Andrey Kuznetsov’s career reached a new peak on Saturday afternoon at the Miami Open presented by Itau.

The 25-year-old controlled his nerves like a veteran and outplayed World No. 4 Stan Wawrinka 6-4, 6-3 in an hour and 19 minutes to move into the third round of the Miami Open for the first time.

Kuznetsov, who’s playing in Miami for the second time of his nine-year career, had never won a match at the tournament before this week. But the World No. 51 looked like the more comfortable player against Wawrinka.

Kuznetsov was more more willing to work the points and stay in rallies than the Swiss, who slapped 34 unforced errors to 16 winners. The Russian also mixed up his attack nicely, rallying with Wawrinka from the baseline and ending points at the net. Kuznetsov won all 11 of the net points he played and hit 22 winners to 21 unforced errors.

He also avenged his straight-set loss to Wawrinka last week in Indian Wells. The Russian also has now won more tour-level matches this year – 12 – than he did during all of 2015 – 10.

Most encouraging for Kuznetsov, though, might have been how he finished on Saturday. He won the final eight points, holding at love and breaking Wawrinka at love as the World No. 4 faltered.

Kuznetsov will face either No. 29 seed American Sam Querrey or Adrian Mannarino of France in the third round.

World No. 6 Kei Nishikori also moved into the third round, dismissing French qualifier Pierre-Hugues Herbert, 6-2, 7-6(4) on Saturday. Herbert had won the doubles title in Indian Wells last weekend with countryman Nicolas Mahut, but Nishikori broke Herbert three times to advance.

Nishikori, who reached the Miami semi-finals in 2013, will play No. 27 seed Alexandr Dolgopolov of Ukraine in the third round. Dolgopolov beat Italy’s Andreas Seppi 6-4, 6-4. Nishikori leads his FedEx ATP Head2Head rivalry against the Ukrainian 3-0.

Canadian Milos Raonic also booked a spot in the third round by winning in straight sets. Raonic beat American Denis Kudla 7-6(4), 6-4. Raonic saved all six break points faced and hit 13 aces against Kudla, No. 63 in the Emirates ATP Rankings.

The No. 12 seed will next face another American Jack Sock. The No. 22 seed won by default when Sergiy Stakhovsky retired down 2-6, 2-3 during their second-round match. Raonic leads his FedEx ATP Head2Head rivalry against Sock 6-1. His only loss occurred the first time they played, on hard courts in 2013 in Memphis.

Gael Monfils also won easily in Miami. In less than an hour, Monfils dismissed Japanese qualifier Tatsuma Ito 6-3, 6-2 on Court 2. The Frenchman struck nine aces and broke Ito three times. The No. 16 seed next will face No. 23 seed Pablo Cuevas of Uruguay, who eliminated John Millman of Australia 7-5, 6-4.

Nick Kyrgios overwhelmed Marcos Baghdatis 6-2, 6-1 in under an hour to advance to the third round. The Aussie excelled in playing first-strike tennis, firing 14 aces and winning 55 per cent of return points against the Cypriot to set up a meeting against Tim Smyczek. Smyczek survived 24 aces from Isner and secured his second victory against a Top-20 player 6-2, 2-6, 7-6(5) when Isner double-faulted on match point.

Roberto Bautista Agut moved into the third round after Aljaz Bedene retired with the Spaniard up 7-5, 2-2.