Matteo Berrettini and Andy Murray will meet in a blockbuster clash on Day Five at the US Open, where the top half of the draw will take to court in third-round action.

Reigning champion Daniil Medvedev will look to continue his title defence when he faces history-maker Wu Yibing, while #NextGenATP Briton Jack Draper aims to build on his standout win against sixth seed Felix Auger-Aliassime when he plays Karen Khachanov.

ATPTour.com looks at five things to watch on Friday in New York.

1) Berrettini & Murray Clash: Berrettini and Murray have tasted success at the hard-court major over the years. The Italian reached the semi-finals in 2019, while Murray lifted his maiden Grand Slam trophy at the event in 2012.

Both will be desperate to create more standout memories in Flushing Meadows over the next week. However, with the pair meeting in the opening match of the day on Arthur Ashe Stadium, only one will be able to continue their journey.

Murray backed up his first-round victory against Francisco Cerundolo by defeating American wild card Emilio Nava to reach the US Open third round for the first time since 2016. The former World No. 1 heads into his match against Berrettini trailing 1-2 in their ATP Head2Head series and expects it to be a difficult test.

“He’s been up at the top of the game for quite a number of years, and now he’s very consistent,” Murray said when asked about the Italian. “He’s a big server who puts down a pretty high percentage of serves usually, so always makes it difficult to break and is always in the match because of that. He’s not just a big server, though. He has a good slice backhand, he has a big forehand. I think he’s a very good competitor as well.”

The 13th seed Berrettini arrived in New York off disappointing first-round exits in Montreal and Cincinnati. The 26-year-old has started to find form, though, defeating Nicolas Jarry and Hugo Grenier in his first two matches. Berrettini holds a 14-4 record at the hard-court major, having reached the quarter-finals last year.

2) Medvedev’s Title Defence Mission: Medvedev has made a perfect start to his US Open title defence this week, cruising past Stefan Kozlov and Arthur Rinderknech in straight sets. The top seed, who defeated Novak Djokovic in the championship match last season, will look to improve his 22-4 record at the major when he faces history-maker Wu Yibing in the night session on Arthur Ashe stadium.

Prior to this week, no Chinese man had competed in the main draw at the US Open in the Open Era. Now they have a player in the third round after the 22-year-old became the first Chinese man to reach the third round at a Grand Slam since Kho Sin-Khie at Wimbledon in 1946.

With the odds stacked against him, Yibing will look to score a seismic upset against Medvedev, who is aiming to capture his second major title and second tour-level crown of the season after he triumphed in Los Cabos in August.

3) Cachin & Draper Look To Continue Runs: Argentine Pedro Cachin dropped to the floor after he edged American qualifier Brandon Holt in a fifth-set tie-break to reach the third round at a major for the first time. The 27-year-old qualifier, who is 52-15 across all levels this year, rallied from two-sets-to-love down to advance on debut in New York. Cachin, currently up to No. 58 in the Pepperstone ATP Live Rankings, will look to carry his momentum into his match against Frenchman Corentin Moutet.

#NextGenATP Briton Jack Draper’s standout season hit new heights on Wednesday when he upset sixth seed Felix Auger-Aliassime in straight sets. The 20-year-old, who is currently fifth in the Pepperstone ATP Live Race To Milan, will next face Karen Khachanov as he aims to reach the fourth round at a major for the first time.

“I’ve watched [Khachanov] a fair bit. A tough competitor. He’s physical,” Draper said when looking ahead to the match. “It’s going to be a really tough match. He’s been inside of the top 50 for a long time now. So in a Grand Slam, it’s going to be a physical match again.”

4) Kyrgios & Ruud Take To Court: Following his second-round win against Benjamin Bonzi, Nick Kyrgios admitted his mentality has changed this season. The Australian, who reached the final at Wimbledon and holds a 33-9 record on the season, revealed he has tried to reinvent himself this year in an attempt to rise to the top of the game again.

So far, it is a strategy that has worked well for the 23rd seed and one he will look to continue when he plays American J.J. Wolf for the first time in the third round on Louis Armstrong Stadium. A victory for Kyrgios will see him reach the fourth round at the US Open for the first time.

Casper Ruud could leave New York as No. 1 in the Pepperstone ATP Rankings if results go his way over the next week. The Norwegian, who has never been beyond the third round in five previous appearances at the US Open, rallied past Tim Van Rijthoven in the second round and will now take on 29th seed Tommy Paul. The American eliminated countryman Sebastian Korda to reach the last 32.

5) Ram/Salisbury Headline Doubles Action: Last year’s champions Rajeev Ram and Joe Salisbury will look to capture their sixth consecutive win when they face Aslan Karatsev and Luke Saville in the second round. The American-British team lifted their third ATP Masters 1000 trophy as a team in Cincinnati last month, before they cruised past Federico Coria and Cristian Rodriguez in their opening match in New York.

Wesley Koolhof and Neal Skupski became the first team to qualify for the Nitto ATP Finals following their first-round win in Flushing Meadows. The second seeds will play Nathaniel Lammons and Jackson Withrow, while third seeds Marcelo Arevalo and Jean-Julien Rojer will face Aleksandr Nedovyesov and Aisam-Ul-Haq Qureshi.

Rafael Nadal was left bloodied but unbeaten after a freak accident late in his four-set win over Fabio Fognini at the US Open Thursday night.

Seeking a record-extending 23rd Grand Slam title, Nadal was cruising towards a comfortable win when he stretched for a wide backhand. His racquet rebounded off the court and onto the bridge of his nose, immediately drawing blood and prompting the Spaniard to walk back to his chair and lay down.

“[It] was just a strong hit. At the beginning I thought I [broke] the nose because it was a shock at the beginning. Was very painful. I lost little bit the… feeling of my head. It’s about being a little bit out of the world,” Nadal said. “I don’t know, seems like it’s not [broken]. I am not sure yet. I don’t know. I think it’s getting bigger and bigger.

“That’s just a shock some way I deserved to play that bad for a while. No, it’s [a joke]. [These are] things that happen sometimes.”

After having a physio apply tape to his nose, Nadal returned to the court a few minutes later to close out the 2-6, 6-4, 6-2, 6-1 victory inside Arthur Ashe Stadium. 

It was a dramatic moment in a dramatic match between the longtime rivals. Fognini led by a set and moved ahead by a break on three occasions in the second set before Nadal found his game to surge ahead. The Spaniard will play former World No. 7 Richard Gasquet on Saturday.

We’re glad you are ok, @RafaelNadal 🙏 pic.twitter.com/t9hzv1QNMH

— US Open Tennis (@usopen) September 2, 2022

“I am practising much, much better than what I am playing. That’s a positive thing. Then I need to make that happen in the matches. It’s something that is not easy. But I’m making a step forward,” Nadal said. “I think at the end of the match today I played better than in the first round without a doubt, too. It’s an improvement. Two matches already. Two victories. That helps. Now another opportunity against Richard.”

With his victory, Nadal qualified for the Nitto ATP Finals for the 17th time. The lefty is the first singles player to earn his spot at the Pala Alpitour from 13-20 November. Wesley Koolhof and Neal Skupski qualified in doubles on Wednesday.

The 22-time major winner significantly reduced his mistakes to remain in the second set despite the deficit he faced. That paid dividends when Fognini’s level dipped, completely changing the momentum of the match.

“I stayed there. I was positive. Even if the disaster was huge, I was not too frustrated,” Nadal said. “Just accepted the situation, stayed humble enough that [I didn’t] consider myself too good to not accept a lot of mistakes.”

Nadal won 17 of the set’s final 21 points to level the clash and from there he surged through the final two sets. The only hiccup came when the freak accident occurred at 3-0 in the fourth set. However, that did not prevent Nadal from powering to the finish line behind nine service breaks. 

“I was [a] little bit in shock. I knew that when I came back on court I [was] going to be in trouble for a while,” Nadal said. “But I needed to save that [service game]… I had a couple of good serves and a good passing shot with the backhand. I won the game.

“Tennis is a lot about moments. The most important thing in this game is when you are playing bad or when the opponent is playing too good, don’t be too far on the score.”

Nadal was well aware of the threat Fognini posed, having let slip a two-set advantage against the Italian in the third round of the US Open in 2015. But despite the slow start, he managed to weather his opponent’s serve. The former Top 10 star’s 60 unforced errors proved his undoing.

Jamie Murray and Bruno Soares cruised through their opening match at the US Open Thursday, defeating Americans Hunter Reese and Max Schnur 6-3, 6-3. Needing just one hour, 13 minutes to seal the victory, Murray and Soares won 24/32 points off their first delivery to advance.

The 10th seeds have fond memories at Flushing Meadows. In 2016, the duo claimed its second Grand Slam title when they triumphed in New York. The pair will next meet Poland’s Hugo Nys and Jan Zielinski in the second round. Murray paired with Australian Matthew Ebden in Winston-Salem this past week to defeat the Polish duo in the championship match.

Sixth seeds Nikola Mektic and Mate Pavic also produced a strong first-round performance, ousting home favourites Brandon Holt and Govind Nanda 6-3, 6-4. The four-time titlists in 2022 face American teenagers Ethan Quinn and Nicholas Godsick in the second round.

Two seeded duos were upset in Thursday afternoon’s action. Italians Lorenzo Sonego and Andrea Vavassori upset ninth seeds Rohan Bopanna and Matwe Middelkoop 7-6(2), 6-2, while Wimbledon champions Max Purcell and Matthew Ebden ousted 14th seeds Santiago Gonzalez and Andres Molteni 7-6(7), 6-7(8), 6-1.

Both pairs will meet American duos in the second round. Sonego and Vavassori will meet Christopher Eubanks and Ben Shelton, while the Australian duo Purcell and Ebden face Robert Galloway and Alex Lawson.

Among other doubles results Thursday, seventh seeds Ivan Dodig and Austin Krajicek advanced, as did 2019 US Open champions Juan Sebastian Cabal and Robert Farah.