A blockbuster quarterfinal between former Grand Slam and Roland Garros champions headlines an enticing slate of quarterfinals in Rome on Friday. We preview the matchups right here at wtatennis.com.

Friday, Quarterfinals

[1] Serena Williams (USA #1) vs. [9] Svetlana Kuznetsova (RUS #19)
Head-to-head: Williams leads, 8-3
Key Stat: Williams has won 72 of her last 76 matches on clay.
Less than two months ago Svetlana Kuznetsova sent Serena Williams tumbling from the Miami draw in stunning fashion, winning 12 of the final 15 games to notch her seventh career victory over a reigning World No.1. That victory snapped Williams’ 20-match winning streak at Miami and put Kuznetsova into the quarterfinals at Key Biscayne for the first time since 2009. Here in Rome, Kuznetsova will try to do the unthinkable again. But three-time champion Williams, who owns a 13-match winning streak at Rome, is looking forward to the challenge of trying to make it 14 against one of the game’s hottest players. “I think right now she’s probably one of the best clay-court players,” Williams said of Kuznetsova on Thursday. “I couldn’t ask for a better match going into Roland Garros, so this is a big opportunity for me, win or lose, to see where I am.”

Pick: Williams in three

[3] Garbiñe Muguruza (ESP #4) vs. [11] Timea Bacsinszky (SUI #10)
Head-to-head: Muguruza leads, 3-0
Key Stat: Muguruza has lost just six games in two rounds in Rome.
Is Garbiñe Muguruza ready to put aside her early season frustrations and break out in a big way on the red clay of Rome? She’s been turning heads with lopsided victories in the last two days over Ekaterina Makarova and Jelena Ostapenko, and even the 22-year-old Spaniard has been impressed with her level of execution in Rome. “I’m thinking everything I tried, everything I did, was working,” Muguruza said after her second-round win on Wednesday. Things have been working pretty well for Timea Bacsinszky as well. The Swiss has won 15 of her last 17 on clay and she battled past last year’s runner-up Carla Suárez Navarro in three sets on Thursday to reach the quarterfinals. Bacsinszky likes to dirty it up and frustrate her opponents with death-defying defense, changes of pace and a wicked backhand. To keep rolling, Muguruza will have to patiently deal with those tactics, paint the lines and look to close at net.

Pick: Muguruza in three

Irina-Camelia Begu (ROU #35) vs. Misaki Doi (JPN #45)
Head-to-head: First meeting
Key Stat: Doi is the lowest-ranked quarterfinalist in Rome.
With three quarterfinals on her last four clay events, Irina-Camelia Begu is starting to look more and more like a Roland Garros dark horse every day. The 25-year-old Romanian has secured Top 10 wins in back-to-back weeks on the European clay, taking out Garbiñe Muguruza in Madrid and Victoria Azarenka in the second round here in Rome. On Friday she’ll face the week’s biggest surprise in Japan’s Misaki Doi. Japan’s No.1 had lost seven straight tour-level matches heading into Rome, but after three consecutive wins (including the two best wins of her career on the dirt rankings-wise) she has earned the best clay-court result of her career. Can she keep the dream alive against Begu or will it be the surging Romanian who moves on to the semis?

Pick: Begu in two

Madison Keys (USA #19) vs. Barbora Strycova (CZE #36)
Head-to-head: Tied, 1-1
Key Stat: Both Keys and Strycova have reached their first quarterfinal at Rome.
One immensely talented youngster is questing to live up to the hype in Rome, while a cagey veteran is playing some of her best clay-court tennis to date. Madison Keys and Barbora Strycova have each managed to play some scintillating tennis at the Foro Italico, and as a result they’ll meet for the second time in as many weeks with a spot in the semifinals on the line. 21-year-old Keys, who is in the early days of her relationship with new coach Thomas Hogstedt, defeated Strycova in straight sets last week in Madrid, and the pair have split their two previous meetings to date. Strycova, not known for her clay prowess, notched her first Top 5 win on the surface last week against Angelique Kerber and has not dropped a set thus far in Rome. Opportunity knocks for both Keys and Strycova in the Eternal City – who will answer the bell?

Pick: Keys in three

-Chris Oddo, wtatennis.com contributor