NEW YORK, NY, USA – With defending champion Flavia Pennetta retiring from tennis at the end of last season, there will be a new champion in Flushing Meadows this year. But will it be a familiar face? Top seed Serena Williams comes into the US Open seeking her seventh title, a record-breaking 23rd major crown, while several former champions loom in the draw as well, like Samantha Stosur, Venus Williams, and Svetlana Kuznetsova. But with the No.1 ranking also at stake, will fellow top seeds Angelique Kerber, Garbiñe Muguruza and Agnieszka Radwanska make their mark?

Read on to delve into the US Open résumés of all the Top 16 seeds…

1. Serena Williams (USA)
17th appearance (84-10)
Best result: Champion (2001-2002, 2008, 2012-2014)
Best Grand Slam result: Champion (22): 1999 US Open, 2002 French Open, 2002 Wimbledon, 2002 US Open, 2003 Australian Open, 2003 Wimbledon, 2005 Australian Open, 2007 Australian Open, 2008 US Open, 2009 Australian Open, 2009 Wimbledon, 2010 Australian Open, 2010 Wimbledon, 2012 Wimbledon, 2012 US Open, 2013 French Open, 2013 US Open, 2014 US Open, 2015 Australian Open, 2015 French Open, 2015 Wimbledon, 2016 Wimbledon

2. Angelique Kerber (GER)
9th appearance (16-8)
Best result: Semifinal (2011)
Best Grand Slam result: Champion (1): 2016 Australian Open

3. Garbiñe Muguruza (ESP)
4th appearance (1-3)
Best result: Second round (2015)
Best Grand Slam result: Champion (1): 2016 French Open

4. Agnieszka Radwanska (POL)
11th appearance (19-10)
Best result: Fourth round (2007-2008, 2012-2013)
Best Grand Slam result: Final (1): 2012 Wimbledon

5. Simona Halep (ROU)
7th appearance (12-6)
Best result: Semifinal (2015)
Best Grand Slam result: Final (1): 2014 French Open

6. Venus Williams (USA)
17th appearance (69-15)
Best result: Champion (2000-2001)
Best Grand Slam result: Champion (7): 2000 Wimbledon, 2000 US Open, 2001 Wimbledon, 2001 US Open, 2005 Wimbledon, 2007 Wimbledon, 2008 Wimbledon

7. Roberta Vinci (ITA)
14th appearance (19-13)
Best result: Final (2015)
Best Grand Slam result: Final (1): 2015 US Open

8. Madison Keys (USA)
5th appearance (5-4)
Best result: Fourth round (2015)
Best Grand Slam result: Semifinal (1): 2015 Australian Open

9. Svetlana Kuznetsova (RUS)
14th appearance (33-12)
Best result: Champion (2004)
Best Grand Slam result: Champion (2): 2004 US Open, 2009 French Open

10. Karolina Pliskova (CZE)
4th appearance (2-3)
Best result: Third round (2014)
Best Grand Slam result: Third round (3): 2014 US Open, 2015 Australian Open, 2016 Australian Open

11. Carla Suárez Navarro (ESP)
9th appearance (11-8)
Best result: Quarterfinal (2013)
Best Grand Slam result: Quarterfinal (5): 2008 French Open, 2009 Australian Open, 2013 US Open, 2014 French Open, 2016 Australian Open

12. Dominika Cibulkova (SVK)
9th appearance (12-8)
Best result: Quarterfinal (2010)
Best Grand Slam result: Final (1): 2014 Australian Open

13. Johanna Konta (GBR)
4th appearance (4-3)
Best result: Fourth round (2015)
Best Grand Slam result: Semifinal (1): 2016 Australian Open

14. Petra Kvitova (CZE)
9th appearance (16-8)
Best result: Quarterfinal (2015)
Best Grand Slam result: Champion (2): 2011 Wimbledon, 2014 Wimbledon

15. Timea Bacsinszky (SUI)
8th appearance (4-7)
Best result: Third round (2008)
Best Grand Slam result: Semifinal (1): 2015 French Open

16. Samantha Stosur (AUS)
13th appearance (21-11)
Best result: Champion (2011)
Best Grand Slam result: Champion (1): 2011 US Open