Serena Williams features on Centre Court, while a host of other second and third-round matchups will take place on Friday. We preview the must-see Day 5 matchups at Wimbledon here, courtesy of wtatennis.com contributor Chris Oddo.

Friday

Second Round and Third Round

[1] Serena Williams (USA #1) vs. Christina McHale (USA #65)
Head-to-head: Williams leads, 2-0
Key Stat: Williams has compiled an 80-10 record in her 17 Wimbledon appearances.

After a three-day rain-induced rest, Serena Williams will get back to the business of defending her Wimbledon title against fellow American Christina McHale in second-round action. Williams has already faced the Teaneck, New Jersey native twice this year, and though she’s come away with two victories the contests have been far from simple. After her three-set victory over McHale in Miami this March, Williams was quick to offer up some kind words about her vanquished foe. “She’s an unbelievably sweet girl,” she said of McHale. “I’ve had the opportunity to play with her on Fed Cup, and we always have such a good time. I think she did a really good job. She can, should, and will be very proud of herself in this match.” The pair would meet again in Rome with Williams winning in straights, but needing a first-set tiebreaker to get through. Naturally Williams will come in as the heavy favorite, but if McHale comes out swinging this could turn into another good battle between compatriots.

Pick: Williams in two

[10] Petra Kvitova (CZE #10) vs. Ekaterina Makarova (RUS #35)
Head-to-head: Kvitova leads, 4-3
Key Stat: Kvitova won 25 of 27 of her first-serve points in her first match at Wimbledon.

Can you say brutal draw? Fans of Petra Kvitova and Ekaterina Makarova surely can, as these two hard-hitting bona fide talents are set to square off in round two. That’s way too early for talents of this level, but as the cliché reads, it is what it is. Makarova certainly does not have the grass pedigree that two-time Wimbledon champion Kvitova has, but the Russian is a former Wimbledon quarterfinalist who missed being seeded at Wimbledon by a whisker this year. She also owns five Top 10 wins on grass, including one against Kvitova at Eastbourne in 2012. But when they met at Wimbledon in 2013, it was Kvitova who came through with a three-set triumph. Kvitova was in devilish form in her opening-round victory over Sorana Cirstea, but she’ll have to keep it up to get past Makarova, who is consistently formidable on grass and at the majors.

Pick: Kvitova in three

[8] Venus Williams (USA #8) vs. [29] Daria Kasatkina (RUS #33)
Head-to-head: Kasatkina Leads, 1-0
Key Stat: Five-time Wimbledon champion Williams leads all active players with 90 main draw matches played at Wimbledon.

One of the more eye-opening victories of the 2016 WTA season came in January, when Daria Kasatkina stunned defending champion Venus Williams in Auckland for her first Top 10 win. Kasatkina, ranked in the 70’s at the time, battled from 3-1 down in set three to win that match and afterwards paid Venus some big-time respect. “She’s an amazing tennis player and I respect her so much,” she said. “It was an unbelievable match for me.” Given that Kasatkina is making her Wimbledon debut, she’s proved to be quite a quick study on grass by reaching round three. But how will she fare against one of the most legendary grass-courters that the game has ever known? An upset at an Australian Open tune-up is certainly notable, but Friday’s task will surely be more daunting for the 19-year-old Russian. And Williams may be the oldest woman in the draw, but she’s making her intentions very clear at SW19. “I want to win,” she said on Thursday after winning her singles and doubles rounds. “I’m not here to not win. What’s the point of being here?”

Pick: Williams in two

Around the Grounds: Many of Thursday’s second-round winners on the lower half will be back in action on Friday. No.9 seed Madison Keys will take on France’s Alizé Cornet. Keys leads the head-to-head 2-0 but the pair have not met since 2014. Will Sabine Lisicki produce another memorable Wimbledon run? The German squares off with former Golden Set winner Yaroslava Shvedova on Court 16. No. 5 seed Simona Halep will meet No.26 seed Kiki Bertens in the last match on No.2 court. Bertens, who produced a career-best semifinal appearance at Roland Garros, is playing the third round at Wimbledon for the first time.

By the Numbers:

21 – Sabine Lisicki’s ace count in her first two rounds. The German is four aces behind Karolina Pliskova for the tournament lead.

6-0, 6-0 – Carina Witthoeft’s double-bagel loss to Angelique Kerber at Wimbledon last year marks the only time she has lost a tour-level match without winning a game. She’ll get a chance for revenge on Friday as she meets Kerber for the second straight year at SW19.

2 – Simona Halep has only won back-to-back matches two times at the All-England Club. The other time was 2014, when she reached the semifinals.